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phenobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may raise the metabolism of ifosfamide to its Lively alkylating metabolites.This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbi